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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TTK
All Species:
34.85
Human Site:
Y568
Identified Species:
63.89
UniProt:
P33981
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P33981
NP_003309.2
857
97072
Y568
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
Chimpanzee
Pan troglodytes
XP_001146752
857
97034
Y568
D
N
Q
T
L
D
S
Y
R
N
E
I
A
Y
L
Rhesus Macaque
Macaca mulatta
XP_001111082
778
87619
L528
K
G
R
I
Y
S
I
L
K
Q
I
G
S
G
G
Dog
Lupus familis
XP_539016
855
96614
Y565
D
N
Q
T
I
E
S
Y
R
N
E
I
A
Y
L
Cat
Felis silvestris
Mouse
Mus musculus
P35761
856
96192
Y567
D
S
Q
T
I
E
S
Y
R
N
E
I
A
F
L
Rat
Rattus norvegicus
NP_001101642
835
94323
Y546
D
S
Q
T
I
D
S
Y
R
N
E
I
A
Y
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512474
935
104827
Y579
D
H
Q
T
I
E
S
Y
Q
N
E
I
A
H
L
Chicken
Gallus gallus
XP_419867
879
99691
Y585
D
Q
Q
T
V
E
S
Y
K
N
E
I
A
H
L
Frog
Xenopus laevis
NP_001082090
882
99060
Y589
D
Q
Q
T
I
E
S
Y
Q
N
E
I
S
H
L
Zebra Danio
Brachydanio rerio
Q8AYG3
982
109993
Y696
D
A
Q
A
V
E
S
Y
K
N
E
I
E
H
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002301009
818
91361
W555
A
H
M
L
A
Q
K
W
K
E
M
D
S
S
N
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_565160
777
86358
W527
D
R
T
I
D
E
N
W
L
R
F
Y
W
Q
Q
Baker's Yeast
Sacchar. cerevisiae
P54199
764
86809
L514
M
G
D
G
L
L
Y
L
I
M
E
C
G
D
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
85.7
87.4
N.A.
74.3
76.9
N.A.
64.2
61
52.8
41.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.6
87.7
92.6
N.A.
84.8
85.6
N.A.
73.6
74.5
68.4
57
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
0
86.6
N.A.
73.3
86.6
N.A.
66.6
66.6
60
53.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
20
100
N.A.
100
100
N.A.
100
93.3
93.3
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
23.1
N.A.
N.A.
22.9
22.7
N.A.
Protein Similarity:
40.2
N.A.
N.A.
42.3
44.5
N.A.
P-Site Identity:
0
N.A.
N.A.
6.6
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
0
8
8
0
0
0
0
0
0
0
54
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
77
0
8
0
8
24
0
0
0
0
0
8
0
8
0
% D
% Glu:
0
0
0
0
0
54
0
0
0
8
77
0
8
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
0
16
0
8
0
0
0
0
0
0
0
8
8
8
8
% G
% His:
0
16
0
0
0
0
0
0
0
0
0
0
0
31
8
% H
% Ile:
0
0
0
16
39
0
8
0
8
0
8
70
0
0
0
% I
% Lys:
8
0
0
0
0
0
8
0
31
0
0
0
0
0
0
% K
% Leu:
0
0
0
8
24
8
0
16
8
0
0
0
0
0
70
% L
% Met:
8
0
8
0
0
0
0
0
0
8
8
0
0
0
0
% M
% Asn:
0
24
0
0
0
0
8
0
0
70
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
16
70
0
0
8
0
0
16
8
0
0
0
8
8
% Q
% Arg:
0
8
8
0
0
0
0
0
39
8
0
0
0
0
0
% R
% Ser:
0
16
0
0
0
8
70
0
0
0
0
0
24
8
0
% S
% Thr:
0
0
8
62
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
16
0
0
0
0
8
0
0
% W
% Tyr:
0
0
0
0
8
0
8
70
0
0
0
8
0
31
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _